Ahead of SOHO Breakthroughs in Blood Cancers—and in the spirit of end-of-year lists—SOHO Insider asked Dr. Vose for her take on the biggest lymphoma developments of 2025. Her answer: bispecific antibodies continue to dominate the field.
She noted that the biggest shift in the field is moving away from chemotherapy alone and toward immunotherapy and bispecific-based approaches.
Dr. Vose will be speaking at 12:30 pm Central time on November 20, 2025, during SBBC. At 12:55 pm Central time, attendees can ask questions via the virtual platform.
Major shift toward integrating bispecifcs
Dr. Vose points to a major shift toward integrating bispecifics in combination regimens with chemotherapy to help patients reach CAR-T or transplant, and now increasingly in frontline therapy for diffuse large B-cell lymphoma and follicular lymphoma.
She highlighted both the STARGLO study, a randomized, global, phase 3 study that is evaluating glofitamab plus gemcitabine and oxaliplatin in the relapsed or refractory setting in DLBCL, and the SUNMO phase 3 trial that is evaluating mosunetuzumab plus polatuzumab vedotin to R-GemOx in transplant-ineligible patients with relapsed or refractory LBCL.
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