Phase 1 study of menin inhibitor terminated early due to lack of response, differentiation syndrome

A first-in-human study of the menin inhibitor DS-1594b in patients with acute leukemias was discontinued early due to lack of.

by Kerri Fitzgerald
December 3, 2025

Extramedullary disease in MM associated with severe toxicities following BCMA-targeted CAR T-cell therapy

Leah Sherwood December 2, 2025

Extramedullary disease (EMD) in multiple myeloma (MM) is associated with significantly higher rates of severe toxicity following B-cell maturation antigen (BCMA)-targeted CAR T-cell therapy, according to a new paper published in Haematologica.

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Drs. Jabbour, Logan, and Aldoss discuss treatment advancements in ALL

SOHO Insider Editors December 1, 2025

In this panel discussion at the Thirteenth Annual Meeting of the Society of Hematologic Oncology (SOHO 2025), Elias Jabbour, MD, leukemia professor at the University of Texas MD Anderson Cancer Center, moderates a discussion on acute lymphoblastic leukemia (ALL) treatment with Aaron Logan, MD, PhD, from the University of California, San Francisco, and Ibrahim T. Aldoss, MD, from the City of Hope.

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Dr. Sundar Jagannath defines ‘cure’ in multiple myeloma

SOHO Insider Editors November 30, 2025

In this interview from the Thirteenth Annual Meeting of the Society of Hematologic Oncology (SOHO 2025), Sundar Jagannath, MD, professor of medicine at the Icahn School of Medicine at Mount Sinai in New York discusses what cure means in multiple myeloma and why there is an urgent need for a formal definition for it in the field.

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FDA adds enterocolitis risk warning to approved CAR-T cell therapy

SOHO Insider Editors November 28, 2025

The US Food and Drug Administration (FDA) approved updates to the prescribing information for ciltacabtagene autoleucel (CARVYKTI). The agency added a boxed warning for immune effector cell-associated enterocolitis (IEC-EC).

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Tara Graff, MD, talks community care and the CAR-T vs bispecific debate

Leah Sherwood November 26, 2025

Society of Hematologic Oncology Insider news

Tara Graff, MD, talks community care and the CAR-T vs bispecific debate

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SOHO Insider lymphoma podcast host Megan Melody, MD, assistant professor at the University of South Florida, interviews Tara Graff, MD, director of clinical trials and lymphoma specialist at Mission Cancer and Blood, part of University of Iowa Health Care, on treating patients with blood cancers in community settings, and whether the future belongs to bispecific antibodies or CAR-T therapies.

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