The Society of Hematologic Oncology (SOHO) was established as a non-profit corporation in 2012 with aims to promote worldwide research, education, prevention, clinical studies and optimal patient care in all aspects of hematologic malignancies and related disorders.
Patients with telomere biology disorders (TBDs) exhibited substantial hematologic and multiorgan morbidity as well as frequent clonal hematopoiesis with a high rate of PPM1D and
The analysis, led by Elias Jabbour, MD, of University of Texas MD Anderson Cancer Center in Houston, was presented at the Fourteenth Annual Meeting of the Society of Hematologic Oncology in Houston, Texas.
The discussion focuses on whether patients in complete molecular remission still need an allogeneic stem cell transplant, alongside methods to prevent T-cell fratricide using CRISPR and base editing. Dr. DiPersio also covers cross-specialty efforts led by pediatric groups like Charles Mulligan and St. Jude’s to decode transcriptional subsets, pointing to international trials across the United States, Europe, and China evaluating off-the-shelf allogeneic products and targeted interventions.
Elritercept, an investigational modified activin receptor type IIA ligand trap, was well-tolerated and associated with rapid, durable transfusion and erythroid responses, including in patients with ring sideroblast (RS)–negative MDS or high transfusion burden.
Ofirnoflast, a first-in-class allosteric NEK7 inhibitor, showed favorable safety and clinically significant efficacy in patients with low-risk myelodysplastic syndromes (LR-MDS) refractory to erythropoietin stimulating agents (ESA).
The study, led by Pina Gabriela Gálvez Zavala Registro, of Universidad Peruana Cayetano Heredia in Lima, Peru, compared patients in the Spanish Group of Myelodysplastic Syndromes (GESMD) national MDS registry with matched general population data to characterize relative survival and mortality outcomes for RS–positive MDS.
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