The Society of Hematologic Oncology (SOHO) was established as a non-profit corporation in 2012 with aims to promote worldwide research, education, prevention, clinical studies and optimal patient care in all aspects of hematologic malignancies and related disorders.
The US Food and Drug Administration has granted Orphan Drug Designation to EO2463 immunotherapy for the treatment of patients with indolent non-Hodgkin lymphoma (iNHL) in
The drug had earlier received the FDA’s breakthrough designation and orphan drug designation, making the application eligible for priority review. Efficacy was evaluated in CADENZA, a multicenter, open-label, single-arm clinical trial that included adult patients with treatment-naïve BPDCN (N=33) or relapsed or refractory BPDCN (N=51), without evidence of active central nervous system disease.
Anthony Stein, MD, of the Gehr Family Center for Leukemia Research at City of Hope in California, and colleagues, conducted the single-center, open-label, phase II study that included patients aged 16 to 60 years with acute myeloid leukemia or acute lymphoblastic leukemia.
As a first-line treatment for patients with marginal zone lymphoma, the combination of bendamustine with rituximab (BR) conferred no advantage in overall survival over rituximab monotherapy, which can yield durable remissions with less toxicity, according to a study published in the journal Haematologica.
The Phase 1 trial evaluates DuoCAR20.19.22-D95 in adults with relapsed or refractory B-cell malignancies who have often failed prior CAR T-cell treatments.
Researchers conducted a systematic review of phase III trials to assess the correlation between these two endpoints in MCL studies. The final analysis included 16 trials assessing 19 treatment options in nearly 6,000 adult patients.
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