The Society of Hematologic Oncology (SOHO) was established as a non-profit corporation in 2012 with aims to promote worldwide research, education, prevention, clinical studies and optimal patient care in all aspects of hematologic malignancies and related disorders.
LB2501 is the first known dual-targeting in vivo CAR-T therapy to receive FDA IND clearance. Built on the proprietary TaVec platform, the off-the-shelf, single-infusion treatment uses an engineered lentiviral vector to generate CD19/CD20 dual-targeting CAR-T cells directly within the patient.
Dr. Komrokji discusses the role of genetic mutations, age-related changes in hematopoiesis and the progression from lower-risk to higher-risk disease. He also reviews diagnostic criteria and the distinction between MDS and related conditions, including clonal cytopenia of undetermined significance and idiopathic cytopenia of undetermined significance.
In this video, which is part of an educational series on myelodysplastic syndromes with SOHO young investigators, Rami Komrokji, MD, leads a discussion on risk stratification and clinical decision-making in MDS, including the use of IPSS-R and IPSS-M, treatment strategies and the timing of stem cell transplantation.
Host Dr. Loretta Nastoupil also discusses with Dr. Xavier how to navigate second-line regimens like monoclonal antibodies versus bispecific T-cell engagers and manage logistical and toxicity concerns in community settings.
“This chemotherapy-blinatumomab risk-oriented program yielded remarkable results that need further improvement in higher-risk patients displaying early MRD persistence,” wrote the study’s authors, led by Renato Bassan, MD, of Ospedale dell’Angelo in Venice, Italy.
The study’s authors, led by Marin Schrappe, MD, of Christian Albrechts University Kiel and University Hospital Schleswig-Holstein in Germany, enrolled pediatric patients with high-risk B-ALL to receive two cycles of either blinatumomab or control chemotherapy after consolidation therapy. The primary end point was EFS based on a time-to-event analysis.
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