
NICE recommends acalabrutinib for mantle cell lymphoma, chronic lymphocytic leukemia
The draft guidance expands frontline options for patients who are ineligible for stem cell transplants or who require oral therapies.
The Society of Hematologic Oncology (SOHO) was established as a non-profit corporation in 2012 with aims to promote worldwide research, education, prevention, clinical studies and optimal patient care in all aspects of hematologic malignancies and related disorders.

The draft guidance expands frontline options for patients who are ineligible for stem cell transplants or who require oral therapies.

Isatuximab-irfc is currently approved across three indications in the US, including in combination with bortezomib, lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma who are not eligible for autologous stem cell transplant, Sanofi reported in the release.

From EHA 2026, Dr. Loretta Nastoupil interviews Dr. Georg Lenz on the phase 3 FRONTMIND study, a randomised, double-blind, placebo-controlled study that evaluated tafasitamab plus lenalidomide and R-CHOP versus R-CHOP for first-line treatment of patients with high-risk diffuse large B-cell lymphoma.

Host Dr. Loretta Nastoupil and guest Dr. Nichols discuss how to build academic partnerships, leverage Blood Cancer United’s free nurse navigation and financial assistance programs, and more.

The results showed a 30% spleen response rate and a 47% symptom response rate among evaluable patients. Overall survival reached around 37 months, which compares favorably to historical controls where survival is typically between one and three years.

William Wierda, MD, PhD, is a professor of medicine and center medical director for the Department of Leukemia, Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center.
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