October 8, 2026
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Incorporating blinatumomab into frontline therapy for high-risk B-ALL improves MRD, survival outcomes

The authors, led by Nicolas Boissel, MD, PhD, of Hôpital Saint-Louis in Paris, France, analyzed 94 patients with high-risk B-ALL who received up to five cycles of blinatumomab during consolidation and maintenance therapy. A post hoc analysis compared outcomes in these patients with outcomes in 90 control patients treated without blinatumomab before QUEST activation. 

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How do the DREAMM-7 and DREAMM-8 trials compare?

“…these are … complementary regimens that could be given to suitable patients,” Dr. Dimopoulos said, explaining how DREAMM-7 fits patients progressing on lenalidomide without prior anti-CD38 exposure, while belantamab mafodotin combined with pomalidomide and dexamethasone suits those resistant to both lenalidomide and anti-CD38.

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