Varun Bafna, MD, of the University of California, San Francisco, provides results from a phase 3 trial of ofirnoflast in ESA-refractory, lower-risk MDS.
Ofirnoflast, a first-in-class, oral, allosteric inhibitor of NEK7, was evaluated in 37 patients and demonstrated clinically meaningful results, according to the investigators, who shared their results at the 2026 EHA Hybrid Congress.

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