EC approves obe-cel for relapsed or refractory B-ALL
The European Commission (EC) has granted marketing authorization to the chimeric antigen receptor T-cell therapy obecabtagene autoleucel (obe-cel; AUCATZYL) for adults ages 26
News
Lymphoma
Indolent B-Cell Lymphomas
EMA grants PRIME designation to Waldenstrom’s macroglobulinemia therapy BGB-16673
The European Medicines Agency (EMA) has granted (PRIority MEdicines) designation to the investigational Bruton’s tyrosine kinase (BTK) degrader, BGB-16673, for the treatment of
Acute Myeloid Leukemia
Investigational CPX-531 plus venetoclax may be a salvage therapy option for relapsed or refractory AML
A study assessed CPX-531 plus venetoclax in patients with relapsed or refractory acute myeloid leukemia (AML) and found that the combination was particularly
Multiple Myeloma
News
Triplet therapy maintains, improves quality of life in relapsed/refractory myeloma
The combination of belantamab mafodotin, bortezomib, and dexamethasone generally maintained or improved health-related quality of life (HRQOL) in patients with relapsed or refractory
Cellular Therapy
News
Study backs liso-cel as second-line treatment in transplant-ineligible LBCL
The final analysis from the phase 2 PILOT study showed that after a median of 18.2 months, response to lisocabtagene maraleucel (liso-cel) was
Multiple Myeloma
Isatuximab approved in the EU for the treatment of transplant-eligible MM
The European Commission has approved isatuximab in combination with bortezomib, lenalidomide, and dexamethasone (VRd) for the induction treatment of adult patients with newly
Acute Myeloid Leukemia
Myelodysplastic Syndromes
News
Combo eprenetapopt plus azacitidine is well-tolerated in TP53-mutated MDS and AML
A phase 2 study found that eprenetapopt plus azacitidine induced responses in patients with TP53-mutated myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). This
Multiple Myeloma
Eque-cel receives Orphan Drug status for myeloma treatment in South Korea
South Korea’s Ministry of Food and Drug Safety (MFDS) granted Orphan Drug Designation to equecabtagene autoleucel (Fucaso; eque-cel) for adults with relapsed or
Lymphoma
Aggressive B-Cell Lymphomas
News
FDA rejects glofitamab-GemOx sBLA in DLBCL
The US Food and Drug Administration (FDA) denied the supplemental Biologics License Application (sBLA) for glofitamab combined with gemcitabine and oxaliplatin (GemOx) for
Leukemia
Acute Myeloid Leukemia
News
Pathways & Perspectives with Alice Mims, MD
Meet Alice Mims, MD, a professor at The Ohio State University and senior medical director of the BeatAML study. Dr. Mims discusses venetoclax’s